A dose-finding study for a supplement containing Lactococcus lactis subsp. cremoris FC in healthy adults with mild constipation

Yayoi Gotoh; Fumio Nanba; Nobuhiko Shioya; Haruhi Sugimura; Toshio Suzuki

doi:10.12938/bmfh.19-009

A dose-finding study for a supplement containing Lactococcus lactis subsp. cremoris FC in healthy adults with mild constipation

Biosci Microbiota Food Health. 2020;39(1):19-22. doi: 10.12938/bmfh.19-009. Epub 2019 Sep 10.

Authors

Yayoi Gotoh¹, Fumio Nanba¹, Nobuhiko Shioya², Haruhi Sugimura³, Toshio Suzuki¹

Affiliations

¹ Fujicco Co., Ltd., 6-13-4 Minatojima-nakamachi, Chuo-ku, Kobe, Hyogo 650-8558, Japan.
² KSO Corporation, 1-9-7-7F Shibaura, Minato-ku, Tokyo 105-0023, Japan.
³ Cestlavie Shimbashi Clinic, Shinkokai Medical Corporation, 2-39-3 Nishi-shimbashi, Minato-ku, Tokyo 105-0003, Japan.

Abstract

A dose-escalation study was conducted to find the effective dose of Lactococcus lactis subsp. cremoris FC for improving defecation in healthy subjects. Twenty-seven subjects were recruited and consecutively ingested a placebo and two dose levels of L. cremoris FC (dose level 1, 1 × 10⁷ cfu; dose level 2, 2 × 10⁷ cfu) capsules daily for two weeks. Frequency of defecation (times/week) was significantly increased by dose level 2, and stool volume (units/week) was significantly increased by dose level 1. This dose-escalation study elucidated that intake of at least 1 × 10⁷ cfu L. cremoris FC improves defecation.

Keywords: Lactococcus lactis; defecation; dose-escalation study; probiotics.