Phosphoinositides in cell proliferation and metabolism

Emilio Hirsch; Federico Gulluni; Miriam Martini

doi:10.1016/j.jbior.2020.100693

Phosphoinositides in cell proliferation and metabolism

Adv Biol Regul. 2020 Jan:75:100693. doi: 10.1016/j.jbior.2020.100693. Epub 2020 Jan 20.

Authors

Emilio Hirsch¹, Federico Gulluni², Miriam Martini²

Affiliations

¹ Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy. Electronic address: emilio.hirsch@unito.it.
² Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.

PMID: 32008962
DOI: 10.1016/j.jbior.2020.100693

Abstract

Phosphoinositides (PI) are key players in many trafficking and signaling pathways. Recent advances regarding the synthesis, location and functions of these lipids have improved our understanding of how and when these lipids are generated and what their roles are in physiology and disease. In particular, PI play a central role in the regulation of cell proliferation and metabolism. Here, we will review recent advances in our understanding of PI function, regulation, and importance in different aspects of proliferation and energy metabolism.

Keywords: Cell metabolism; PI3K; Phosphoinositides; Proliferation; mTOR.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Energy Metabolism*
Humans
Phosphatidylinositols / genetics
Phosphatidylinositols / metabolism*
Protein Transport
Signal Transduction*

Substances

Phosphatidylinositols