Using extremal events to characterize noisy time series

J Math Biol. 2020 Apr;80(5):1523-1557. doi: 10.1007/s00285-020-01471-4. Epub 2020 Feb 1.

Abstract

Experimental time series provide an informative window into the underlying dynamical system, and the timing of the extrema of a time series (or its derivative) contains information about its structure. However, the time series often contain significant measurement errors. We describe a method for characterizing a time series for any assumed level of measurement error [Formula: see text] by a sequence of intervals, each of which is guaranteed to contain an extremum for any function that [Formula: see text]-approximates the time series. Based on the merge tree of a continuous function, we define a new object called the normalized branch decomposition, which allows us to compute intervals for any level [Formula: see text]. We show that there is a well-defined total order on these intervals for a single time series, and that it is naturally extended to a partial order across a collection of time series comprising a dataset. We use the order of the extracted intervals in two applications. First, the partial order describing a single dataset can be used to pattern match against switching model output (Cummins et al. in SIAM J Appl Dyn Syst 17(2):1589-1616, 2018), which allows the rejection of a network model. Second, the comparison between graph distances of the partial orders of different datasets can be used to quantify similarity between biological replicates.

Keywords: Merge trees; Order of extrema; Partial orders; Time series.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Algorithms
  • Causality
  • Cell Cycle / genetics
  • Computational Biology
  • Databases, Factual / statistics & numerical data
  • Gene Regulatory Networks
  • Interrupted Time Series Analysis / statistics & numerical data
  • Linear Models
  • Mathematical Concepts
  • Models, Biological*
  • Models, Genetic
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / genetics
  • Signal-To-Noise Ratio
  • Time Factors