Altered plasma prostaglandin E2 levels in epilepsy and in response to antiepileptic drug monotherapy

Abstract

Prostaglandin E₂ (PGE₂), a physiologically active lipid compound, is increased in several diseases characterized by chronic inflammation. To determine its significance in epilepsy-associated inflammation and response to antiepileptic drug (AED), we evaluated the plasma PGE₂ (median, pg/ml) levels in drug-free patients with epilepsy (N = 34) and patients receiving AED monotherapy (N = 55) in addition to that in healthy controls (N = 34). When compared to controls, plasma PGE₂ levels were significantly elevated in all drug-free patients independent of the type of epilepsy (137.2 versus 475.7 pg/ml, p < 0.0001). Among the patients receiving AED monotherapy, only valproate responders showed a significant decrease compared to both drug-free patients (232.1 versus 475.7 pg/ml, p < 0.01) as well as valproate non-responders (232.1 versus 611.9 pg/ml, p < 0.0001). Both responders and non-responders on phenytoin or carbamazepine monotherapy had elevated PGE₂ levels similar to drug-free patients. In addition, no difference was observed in plasma profiles of PGE₂ precursor, arachidonic acid among the groups. Our work presents the clinical evidence of the association between plasma PGE₂ levels and valproate efficacy in patients with epilepsy.

Keywords: Arachidonic acid; Carbamazepine; Epilepsy; Phenytoin; Prostaglandin E(2) (PGE(2)); Valproate.