Abstract
Type 2 diabetes mellitus is often companied with osteoporosis, a process which involves osteoclast activation. In this study, we found tubeimoside I, a natural compound isolated from the Chinese medicinal herb Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae), significantly ameliorated the decrease of bone mass in type 2 diabetes-induced osteoporosis in rats. It appears that tubeimoside I exerts this protecting effect through inhibiting osteoclast formation and function. Futhermore, our study showed that tubeimoside I inhibits NF-κB transcriptional activation and degradation of IκBα. Collectively, our results reveal that tubeimoside I attenuates osteoclastogenesis through down-regulating NF-κB signaling pathway, and is a potential candidate for the treatment of bone-destructive diseases like type 2 diabetic osteoporosis.
Keywords:
Nuclear factor‐κB; Osteoclasts; Tubeimoside I.
Copyright © 2020 Elsevier B.V. All rights reserved.
MeSH terms
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Animals
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Bone Resorption / etiology
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Bone Resorption / pathology
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Bone Resorption / prevention & control*
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Diabetes Mellitus, Experimental / chemically induced
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Diabetes Mellitus, Experimental / complications
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Diabetes Mellitus, Experimental / drug therapy*
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Diabetes Mellitus, Type 2 / chemically induced
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Diabetes Mellitus, Type 2 / complications
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Diabetes Mellitus, Type 2 / drug therapy*
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Down-Regulation / drug effects
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Humans
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Male
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Mice
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NF-KappaB Inhibitor alpha / metabolism
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NF-kappa B / metabolism
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Osteoclasts / drug effects
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Osteogenesis / drug effects
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Osteoporosis / etiology
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Osteoporosis / pathology
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Osteoporosis / prevention & control*
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Primary Cell Culture
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Proteolysis / drug effects
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RANK Ligand / metabolism
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RAW 264.7 Cells
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Rats
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Saponins / pharmacology*
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Saponins / therapeutic use
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Signal Transduction / drug effects
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Specific Pathogen-Free Organisms
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Streptozocin / toxicity
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Triterpenes / pharmacology*
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Triterpenes / therapeutic use
Substances
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NF-kappa B
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Nfkbia protein, rat
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RANK Ligand
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Saponins
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Triterpenes
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tubeimoside I
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NF-KappaB Inhibitor alpha
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Streptozocin