Abstract
Lysophosphatidic acid (LPA) species are present in almost all organ systems and play diverse roles through its receptors. Asthma is an airway disease characterized by chronic allergic inflammation where various innate and adaptive immune cells participate in establishing Th2 immune response. Here, we will review the contribution of LPA and its receptors to the functions of immune cells that play a key role in establishing allergic airway inflammation and aggravation of allergic asthma.
Keywords:
Airway inflammation; Asthma; Autotaxin; Lysophosphatidic acid; Lysophosphatidic acid receptors.
Published by Elsevier B.V.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Asthma / blood
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Asthma / genetics
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Asthma / immunology*
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Asthma / pathology
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Cell Movement / immunology
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Dendritic Cells / immunology
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Dendritic Cells / metabolism
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Disease Models, Animal
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Endothelial Cells / immunology
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Endothelial Cells / metabolism
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Endothelium, Vascular / cytology
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Endothelium, Vascular / immunology
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Endothelium, Vascular / metabolism
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Gene Knock-In Techniques
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Humans
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Lung / blood supply
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Lung / cytology
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Lung / immunology
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Lung / pathology
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Lymph Nodes / blood supply
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Lymph Nodes / immunology
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Lymph Nodes / metabolism
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Lysophospholipids / metabolism*
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Macrophages, Alveolar / immunology
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Macrophages, Alveolar / metabolism
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Mice
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Mice, Knockout
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Phosphoric Diester Hydrolases / genetics
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Phosphoric Diester Hydrolases / metabolism*
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Receptors, Lysophosphatidic Acid / genetics
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Receptors, Lysophosphatidic Acid / metabolism*
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Signal Transduction / immunology*
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Th2 Cells / immunology
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Th2 Cells / metabolism
Substances
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Lysophospholipids
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Receptors, Lysophosphatidic Acid
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Phosphoric Diester Hydrolases
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alkylglycerophosphoethanolamine phosphodiesterase
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lysophosphatidic acid