Abstract
It is commonly assumed that beneficial adaptations in bone occur with vigorous exercise, yet any adaptive re/modeling in bone undergoing persistent overloading can be counteracted by superimposed inflammatory, compressive, and tensile loading-induced damage responses above thresholds of tissue fatigue failure and repair. This leads to a tenuous balance between achieving bone accrual and loss.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Accidents, Occupational
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Adaptor Proteins, Signal Transducing / metabolism
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Animals
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Bone Density / physiology
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Bone Resorption*
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Bone and Bones / innervation
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Cumulative Trauma Disorders / physiopathology
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Exercise / physiology
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Humans
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Models, Animal
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Occupations*
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Osteocytes / metabolism
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Osteogenesis / physiology*
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Physical Exertion / physiology*
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RANK Ligand / metabolism
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Stress, Mechanical
Substances
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Adaptor Proteins, Signal Transducing
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RANK Ligand
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SOST protein, human
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TNFSF11 protein, human