Finding vacuolated lymphocytes in fetal effusions improves the prenatal diagnosis of lysosomal storage diseases

Prenat Diagn. 2020 Apr;40(5):605-611. doi: 10.1002/pd.5657. Epub 2020 Feb 11.

Abstract

Objectives: There are many causes of fetal effusions, including the rare lysosomal storage diseases (LSDs). Vacuolated lymphocytes (VLs) are found in the blood of infants with LSDs, and their presence in fetal effusion could increase the risk of underlying LSD.

Methods: Between 2006 and 2018, all fetal effusions samples from 43 fetal multidisciplinary centers were referred to a single laboratory. Cells were counted, and, if observed, VLs were categorized and counted. Screening for LSDs was performed by metabolite analyses on amniotic fluid supernatant. The diagnosis of an LSD was confirmed by measuring the activity of the corresponding enzyme and/or mutation analysis.

Results: Our laboratory received 614 ascitic fluids and 280 pleural fluids sampled between 22 and 33 weeks of gestation. The final diagnosis was LSD in 16 cases (1.8%). VLs were reported in all these 16 cases, in a mix of lymphocytes with and without vacuoles. Vacuoles in VLs varied in size and number. In most cases, VLs were easy to recognize, with numerous, large, round, well-defined vacuoles, but in three cases of LSDs, VLs were atypical.

Conclusion: The finding of VLs in fetal effusions is an inexpensive first-line test that may help to prioritize biochemical and genetic tests for LSDs.

MeSH terms

  • Ascites / pathology*
  • Ascitic Fluid / pathology
  • Female
  • Gangliosidosis, GM1 / diagnosis
  • Gangliosidosis, GM1 / pathology
  • Humans
  • Lymphocytes / pathology*
  • Lysosomal Storage Diseases / diagnosis
  • Lysosomal Storage Diseases / pathology*
  • Mucolipidoses / diagnosis
  • Mucolipidoses / pathology
  • Mucopolysaccharidosis VII / diagnosis
  • Mucopolysaccharidosis VII / pathology
  • Niemann-Pick Disease, Type C / diagnosis
  • Niemann-Pick Disease, Type C / pathology
  • Pleural Effusion / pathology*
  • Pregnancy
  • Prenatal Diagnosis
  • Sensitivity and Specificity
  • Sialic Acid Storage Disease / diagnosis
  • Sialic Acid Storage Disease / pathology
  • Vacuoles / pathology*

Supplementary concepts

  • Neuraminidase 1 deficiency
  • Neuraminidase deficiency with beta-galactosidase deficiency