Destroy, what destroys you

Khang Luu; Emily Nickles; Herbert Schwarz

doi:10.1080/2162402X.2019.1685301

Destroy, what destroys you

Oncoimmunology. 2019 Nov 3;9(1):1685301. doi: 10.1080/2162402X.2019.1685301. eCollection 2020.

Authors

Khang Luu^{1

2}, Emily Nickles¹, Herbert Schwarz^{1

2}

Affiliations

¹ Department of Physiology, and Immunology Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
² Graduate School for Integrative Sciences & Engineering, National University of Singapore, Singapore, Singapore.

Abstract

New evidence indicates the importance of CD137 for controlling Epstein-Barr virus (EBV) infections. (1) Mutations in CD137 predispose to EBV-associated diseases. (2) EBV induces ectopic CD137 expression, thereby activating a negative feed-back regulation and reducing T cell costimulation. These findings suggest CD137 agonists as new treatments for EBV-associated diseases.

Keywords: CD137; Epstein-Barr virus; Hodgkin lymphoma; mutations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Epstein-Barr Virus Infections*
Herpesvirus 4, Human / genetics
Humans

Grants and funding

This work was supported by the National Medical Research Council Singapore [NMRC/OFIRG/0022/2016].