Abstract
T-cell recognizable p53 hotspot mutations offer opportunities for immunotherapy and immune monitoring. Recognition of p53 mutations by peripheral blood CD8 and CD4 T lymphocytes has been revealed.See related article by Malekzadeh et al., p. 1267.
©2020 American Association for Cancer Research.
Publication types
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Antigens, Neoplasm* / genetics
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CD4-Positive T-Lymphocytes / metabolism
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Humans
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Immunotherapy
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Receptors, Antigen, T-Cell / genetics
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Receptors, Antigen, T-Cell / metabolism
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Tumor Suppressor Protein p53* / genetics
Substances
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Antigens, Neoplasm
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Receptors, Antigen, T-Cell
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Tumor Suppressor Protein p53