Macrophage-based nanotherapeutic strategies in ulcerative colitis

Jiaxin Zhang; Yuge Zhao; Tianling Hou; Hairong Zeng; Dipika Kalambhe; Bing Wang; Xiaoyan Shen; Yongzhuo Huang

doi:10.1016/j.jconrel.2020.01.047

Macrophage-based nanotherapeutic strategies in ulcerative colitis

J Control Release. 2020 Apr 10:320:363-380. doi: 10.1016/j.jconrel.2020.01.047. Epub 2020 Jan 27.

Authors

Jiaxin Zhang¹, Yuge Zhao², Tianling Hou³, Hairong Zeng⁴, Dipika Kalambhe⁵, Bing Wang⁶, Xiaoyan Shen⁷, Yongzhuo Huang⁸

Affiliations

¹ School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
² State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China; School of Pharmacy, Nanchang University, Nanchang, China.
³ Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA, USA.
⁴ Department of Pharmacy, Putuo hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
⁵ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China; University of Chinese Academy of Sciences, Beijing, China.
⁶ School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. Electronic address: bwang@simm.ac.cn.
⁷ Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.
⁸ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China; University of Chinese Academy of Sciences, Beijing, China. Electronic address: yzhuang@simm.ac.cn.

PMID: 32001299
DOI: 10.1016/j.jconrel.2020.01.047

Abstract

Macrophages, an important component of the innate immune response, are a key regulator of intestinal microenvironment homeostasis. These cells essentially contribute to chronic inflammatory diseases due to their strong plasticity. As is known, ulcerative colitis (UC), a chronic inflammatory disease, is closely related to immune dysfunction. A growing body of evidence suggests that the macrophage is a promising drug target for modulating the intestinal immune systems and regulating the inflammatory microenvironment, thus alleviating the inflammatory responses in UC. The macrophage-based therapy strategies for UC are still at an emerging stage. The advanced drug delivery systems can improve the macrophage-based therapy. This article will review the molecular mechanisms related to macrophage polarization and the interactions between signaling pathways that regulate the pathogenesis of UC and summarize the macrophage-based nanotherapeutic strategies in UC.

Keywords: Drug delivery system; Inflammation; Macrophage; Nanomedicine; Ulcerative colitis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Colitis, Ulcerative* / drug therapy
Humans
Intestines
Macrophage Activation
Macrophages
Signal Transduction