Regulatory Actions of Estrogen Receptor Signaling in the Cardiovascular System

Kazutaka Ueda; Yusuke Adachi; Pangyen Liu; Nobuaki Fukuma; Eiki Takimoto

doi:10.3389/fendo.2019.00909

Regulatory Actions of Estrogen Receptor Signaling in the Cardiovascular System

Front Endocrinol (Lausanne). 2020 Jan 10:10:909. doi: 10.3389/fendo.2019.00909. eCollection 2019.

Authors

Kazutaka Ueda¹, Yusuke Adachi¹, Pangyen Liu¹, Nobuaki Fukuma¹, Eiki Takimoto^{1

2}

Affiliations

¹ Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
² Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Abstract

Premenopausal females have a lower incidence of death from cardiovascular disease (CVD) than male counterparts, supporting the notion that estrogen is protective against the development and progression of CVD. Although large-scale randomized trials of postmenopausal hormone replacement therapy failed to show cardiovascular benefits, recent ELITE study demonstrated anti-atherosclerotic benefits of exogenous estrogen depending on the initiation timing of the therapy. These results have urged us to better understand the mechanisms for actions of estrogens on CVD. Here, we review experimental and human studies, highlighting the emerging role of estrogen's non-nuclear actions linking to NO-cGMP signaling pathways.

Keywords: animal study; cardiovascular diseases; estrogen; non-nuclear pathway; receptor signaling.

Publication types

Review