Circular RNA and Diabetes: Epigenetic Regulator with Diagnostic Role

Kazem Abbaszadeh-Goudarzi; Shabnam Radbakhsh; Mohammad Hossein Pourhanifeh; Hashem Khanbabaei; Amirhosein Davoodvandi; Hadis Fathizadeh; Amirhossein Sahebkar; Mohammad Karim Shahrzad; Hamed Mirzaei

doi:10.2174/1566524020666200129142106

Circular RNA and Diabetes: Epigenetic Regulator with Diagnostic Role

Curr Mol Med. 2020;20(7):516-526. doi: 10.2174/1566524020666200129142106.

Authors

Kazem Abbaszadeh-Goudarzi¹, Shabnam Radbakhsh², Mohammad Hossein Pourhanifeh³, Hashem Khanbabaei⁴, Amirhosein Davoodvandi⁵, Hadis Fathizadeh⁶, Amirhossein Sahebkar⁷, Mohammad Karim Shahrzad⁸, Hamed Mirzaei⁹

Affiliations

¹ Cellular and Molecular Research Center, Department of Biochemistry and Nutrition, Sabzevar University of Medical Sciences, Sabzevar, Iran.
² Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Halal Research Center of IRI, FDA, Tehran, Iran.
⁴ Radiobiology Laboratory, Medical Physics Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
⁵ Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran.
⁶ Department of Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
⁷ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
⁸ Department of Internal Medicine and endocrinology, Shohadae Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁹ Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.

PMID: 31995005
DOI: 10.2174/1566524020666200129142106

Abstract

Circular RNAs, a group of endogenous non-coding RNAs, are characterized by covalently closed cyclic structures with no poly-adenylated tails. It has been recently recommended that cirRNAs have an essential role in regulating genes expression by functioning as a translational regulator, RNA binding protein sponge and microRNA sponge. Due to their close relation to the progression of various diseases such as diabetes, circRNAs have become a research hotspot. A number of circRNAs (i.e., circRNA_0054633, circHIPK3, circANKRD36, and circRNA11783-2) have been shown to be associated with initiation and progression of diabetes. Based on reports, in a tissue, some circRNAs are expressed in a developmental stage-specific manner. In this study, we reviewed research on circular RNAs involved in the pathogenesis and diagnosis of diabetes and their prognostic roles.

Keywords: Circular RNA; biomarker; circANKRD36; circHIPK3; circRNA_0054633; diabetes.

Publication types

Review

MeSH terms

Animals
Diabetes Mellitus / diagnosis*
Diabetes Mellitus / genetics
Epigenesis, Genetic*
Humans
MicroRNAs / genetics*
Prognosis
RNA, Circular / genetics*

Substances

MicroRNAs
RNA, Circular