Histological characteristics of early-stage oral tongue cancer in young versus older patients: A multicenter matched-pair analysis

Ibrahim O Bello; Alhadi Almangush; Ilkka Heikkinen; Caj Haglund; Ricardo D Coletta; Luiz P Kowalski; Antti A Mäkitie; Pentti Nieminen; Ilmo Leivo; Tuula Salo

doi:10.1111/odi.13288

Histological characteristics of early-stage oral tongue cancer in young versus older patients: A multicenter matched-pair analysis

Oral Dis. 2020 Jul;26(5):1081-1085. doi: 10.1111/odi.13288. Epub 2020 Feb 14.

Authors

Ibrahim O Bello^{1

2}, Alhadi Almangush^{2

3

4}, Ilkka Heikkinen², Caj Haglund^{5

6}, Ricardo D Coletta⁷, Luiz P Kowalski^{8

9}, Antti A Mäkitie^{10

11

12}, Pentti Nieminen¹³, Ilmo Leivo³, Tuula Salo^{2

14

15}

Affiliations

¹ Department of Oral Medicine and Diagnostic Sciences, King Saud University, Riyadh, Saudi Arabia.
² Department of Pathology, University of Helsinki, Helsinki, Finland.
³ Institute of Biomedicine, Pathology, University of Turku, Turku, Finland.
⁴ Faculty of Dentistry, University of Misurata, Misurata, Libya.
⁵ Research Programs Unit, Translational Cancer Biology, University of Helsinki, Helsinki, Finland.
⁶ Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
⁷ Department of Oral Diagnosis, School of Dentistry, University of Campinas, Piracicaba, São Paulo, Brazil.
⁸ Department of Head and Neck Surgery and Otorhinolaryngology, AC Carmago Cancer Center, Sao Paulo, Brazil.
⁹ Head and Neck Surgery Department, University of Sao Paulo Medical School, Sao Paulo, Brazil.
¹⁰ Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
¹¹ Research Programme in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
¹² Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
¹³ Medical Informatics and Data Analysis Research Group, University of Oulu, Oulu, Finland.
¹⁴ Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.
¹⁵ Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.

PMID: 31994277
DOI: 10.1111/odi.13288

Abstract

Little is known about the histopathological characteristics that may differentiate early oral tongue cancer (OTSCC) between young and older patients. From a total of 311 cases diagnosed with clinically early-stage OTSCC at 6 institutions, only 42 patients were young patients were aged ≤45 years. For comparison, 42 patients >60 years old were matched for center of management, clinical stage and gender. We compared epithelial and stromal histopathologic parameters between the two groups. Most of the parameters were similar between the two groups, although the young patients appeared to have marginally higher intensity of tumor budding, histologic risk score, infiltrative pattern of invasion and tumor-stroma ratio. However, none of the factors showed significant difference when comparing the two groups. The histological parameters reflect mechanisms of invasive growth and tissue response to invasive growth, but not the etiological difference in OTSCC between young and older patients. Further investigations are necessary to compare the genetic background of early OTSCC in the two groups.

Keywords: early-stage; histopathological characteristics; matched-pair analysis; oral tongue cancer; young.

Publication types

Multicenter Study

MeSH terms

Adult
Carcinoma, Squamous Cell* / pathology
Humans
Matched-Pair Analysis
Middle Aged
Mouth Neoplasms* / pathology
Neoplasm Staging
Tongue Neoplasms* / pathology

Abstract

Publication types

MeSH terms

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