Author's View: a nuclear transcription factor relocalizing to mitochondria rescues cells from proteotoxic aggregates

Asli Aras Taskin; Daniel Poveda-Huertes; F-Nora Vögtle

doi:10.1080/23723556.2019.1698256

Author's View: a nuclear transcription factor relocalizing to mitochondria rescues cells from proteotoxic aggregates

Mol Cell Oncol. 2019 Dec 10;7(1):1698256. doi: 10.1080/23723556.2019.1698256. eCollection 2020.

Authors

Asli Aras Taskin^{1

2}, Daniel Poveda-Huertes¹, F-Nora Vögtle^{1

2}

Affiliations

¹ Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
² CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.

Abstract

Mitochondrial proteostasis is essential for survival, and imbalances can result in severe human diseases. We identified a novel stress response triggered upon accumulation of proteotoxic aggregates in the mitochondrial matrix. Mitochondria-to-nucleus signaling results in a transcriptional response and translocation of a nuclear transcription factor into mitochondria to maintain mitochondrial gene expression.

Keywords: Mitochondria-to-nucleus communication; dual targeting; mitochondrial proteostasis; mitochondrial unfolded protein response; protein biogenesis.

Grants and funding

Our work is funded by the Emmy-Noether program of the Deutsche Forschungsgemeinschaft, the SFB1381 [Project ID 403222702] and Germany’s Excellence Strategy [CIBSS - EXC-2189 - Project ID 390939984] and the RTG2202.