Emerging role of long non-coding RNAs in cancer precision medicine

Aritro Nath; R Stephanie Huang

doi:10.1080/23723556.2019.1684130

Emerging role of long non-coding RNAs in cancer precision medicine

Mol Cell Oncol. 2019 Nov 10;7(1):1684130. doi: 10.1080/23723556.2019.1684130. eCollection 2020.

Authors

Aritro Nath¹, R Stephanie Huang²

Affiliations

¹ Department of Medical Oncology and Therapeutics Research, City of Hope, Duarte, LA, USA.
² Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, USA.

Abstract

A vast majority of the human genome encodes long non-coding RNAs (lncRNAs) as compared to protein-coding genes (PCGs). But most efforts to determine biomarkers of anticancer drug response have focused entirely on PCGs. Comprehensive investigation of lncRNAs and drug response demonstrates that lncRNAs are indeed crucial biomarkers of drug response.

Keywords: Long non-coding RNA; drug response prediction; pharmacogenomics.

Grants and funding

R01 CA204856/CA/NCI NIH HHS/United States