RETRACTED: Long non-coding RNA LINC00525 promotes the non-small cell lung cancer progression by targeting miR-338-3p/IRS2 axis

Biomed Pharmacother. 2020 Apr:124:109858. doi: 10.1016/j.biopha.2020.109858. Epub 2020 Jan 25.

Abstract

This article has been retracted at the request of the Editor-in-Chief. The corresponding author notified the journal that in vivo and transwell invasion experimental results reported in this study were not reproducible. As the results were unreliable the authors requested its retraction. The journal was also alerted to several suspected image similarities within Figures 3B and 6D, that appear to be present in other publications, as detailed here: https://pubpeer.com/publications/9F5D26FDF83E716B615F407B35ED8B#. The journal requested the authors provide explanations and source data relating to these affected figures. Authors were not able to satisfy this request. The Editor-in-Chief assessed this case and decided to retract the article.

Keywords: IRS2; LINC00525; Non-small cell lung cancer; miR-338-3p.

Publication types

  • Retracted Publication

MeSH terms

  • A549 Cells
  • Animals
  • Carcinoma, Non-Small-Cell Lung / genetics
  • Carcinoma, Non-Small-Cell Lung / pathology*
  • Cell Line, Tumor
  • Cell Movement / genetics
  • Cell Proliferation / genetics
  • Disease Progression
  • Gene Expression Regulation, Neoplastic
  • Gene Knockdown Techniques
  • Humans
  • Insulin Receptor Substrate Proteins / genetics
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • MicroRNAs / genetics*
  • RNA, Long Noncoding / genetics*
  • Xenograft Model Antitumor Assays

Substances

  • IRS2 protein, human
  • Insulin Receptor Substrate Proteins
  • MIRN338 microRNA, human
  • MicroRNAs
  • RNA, Long Noncoding