Atherosclerosis is regarded as a lipid-driven chronic inflammatory disease. A variety of immune cells, including B1 cells, play an important role in the occurrence and development of atherosclerosis. T15/E06 is an IgM Nab secreted by B1 cells. The concentration of T15/E06 is significantly decreased in animal models of atherosclerosis. Accumulating evidence has shown that T15/E06 can protect against atherosclerosis by blocking macrophage lipid uptake, inhibiting vascular inflammation, and promoting apoptotic cell clearance. In this review, we describe the structure, functions and regulation of T15/E06 and summarize the latest advance regarding its atheroprotective effect.
Keywords: Atherosclerosis; IgM Nabs; Inflammatory response; Lipid metabolism; T15/E06.
Copyright © 2020. Published by Elsevier B.V.