Abstract
Novel biotinylated diazido-Pt(iv) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all-trans-[Pt(py)2(N3)2(biotin)(OH)] (2a) were enhanced significantly when bound to avidin; irradiation induced dramatic cellular morphological changes in human ovarian cancer cells treated with 2a.
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Biotinylation*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Female
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Humans
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Molecular Structure
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Optical Imaging
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Organoplatinum Compounds / chemical synthesis
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Organoplatinum Compounds / chemistry*
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Organoplatinum Compounds / pharmacology*
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Ovarian Neoplasms / diagnostic imaging
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Ovarian Neoplasms / drug therapy*
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Ovarian Neoplasms / pathology
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Photochemical Processes
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Organoplatinum Compounds