Variable Outcome of Acute Viral Hepatitis in Diabetic and Nondiabetic Patients in Bangladesh

Harun Or Rashid; Mahbubur R Khan; Tasnova Rashid; Humaira Rashid; Mamun Al Mahtab

doi:10.5005/jp-journals-10018-1290

Variable Outcome of Acute Viral Hepatitis in Diabetic and Nondiabetic Patients in Bangladesh

Euroasian J Hepatogastroenterol. 2019 Jan-Jun;9(1):20-22. doi: 10.5005/jp-journals-10018-1290.

Authors

Harun Or Rashid¹, Mahbubur R Khan¹, Tasnova Rashid², Humaira Rashid³, Mamun Al Mahtab⁴

Affiliations

¹ Department of Hepatology, Rajshahi Medical College Hospital, Rajshahi, Bangladesh.
² Department of Medicine, Medical College for Women and Hospital, Dhaka, Bangladesh.
³ Department of Pharmacy, Brac University, Dhaka, Bangladesh.
⁴ Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.

Abstract

Diabetes mellitus (DM) are common in Bangladesh, and this country is also well-known for frequent outbreaks of acute viral hepatitis (AVH). The study presented here was designed for the clinical courses of acute hepatitis with and without DM. A total of 300 patients with AVH were enrolled into two groups; group A; patients of AVH with DM (N = 140) and group B; patients with AVH without DM (N = 160). There was no significant difference regarding age, sex, and levels of alanine aminotransferase (ALT) between the two groups. The main cause of AVH was hepatitis E virus (HEV) in 100 and 112 patients of groups A and B, respectively. Jaundice persisted for more than 6 months in 68 of 140 (49%) patients of group A, whereas, this was found in only 11 of 160 patients of group B. Forty-two patients of group A showed evidence of esophageal varices; however, the endoscopic assessment did not reveal any abnormality in patients with group B. Moderate to several hepatic fibrosis was seen in 19 of 140 patients with group A, however, these were not detected in any patient of group B (patient with AVH without DM). Even more important is the fact that four patients of group A died of liver failure, whereas there was no mortality in any patient of group B. The study presented here indicates that all patients with DM with superimposed AVH should be carefully followed up with the possibility of development of severe liver diseases and even mortality. How to cite this article: Harun-or-Rashid, Khan MR, et al. Variable Outcome of Acute Viral Hepatitis in Diabetic and Nondiabetic Patients in Bangladesh. Euroasian J Hepatogastroenterol 2019;9(1): 20-22.

Keywords: Acute viral hepatitis; Diabetes mellitus; Hepatitis E virus.