The Arrhenius activation energy and binary chemical reaction are taken into account to consider the magnetohydrodynamic mixed convection second grade nanofluid flow through a porous medium in the presence of thermal radiation, heat absorption/generation, buoyancy effects and entropy generation. The items composing of the governing systems are degenerated to nonlinear ordinary differential equations by adopting the appropriate similarity transformations which are computed through Runge-Kutta-Fehlberg (RKF) numerical technique along with Shooting method. The solution is manifested through graphs which provides a detailed explanations of each profile in terms of involved parameters effects. The compared results maintain outstanding approach to the previous papers.