Molybdenum sulfide-based electrochemical platform for high sensitive detection of taxifolin in Chinese medicine

Anal Chim Acta. 2020 Feb 22:1099:85-93. doi: 10.1016/j.aca.2019.11.057. Epub 2019 Nov 29.

Abstract

MoS2 and nitrogen doped active carbon composite (MoS2/ANC) is fabricated to detect taxifolin and exhibits superior redox current response and decreased redox potential difference. Further investigation reveals that the kinetic process of the redox reaction of taxifolin on MoS2/ANC electrode is controlled by both adsorption and diffusion process. Under the optimum conditions, the redox peak currents linearly relate with the concentration of taxifolin in the range of 1 × 10-9-1 × 10-6 mol L-1, accompanied by the low detection limit (3 × 10-10 mol L-1). Meanwhile, outstanding selectivity, stability and repeatability are also obtained at MoS2/ANC electrode. At last, the proposed method is applied to quantitatively detect taxifolin in fructus polygoni orientalis and satisfactory results have been achieved.

Keywords: Fructus polygoni; Molybdenum sulfide; Porous carbon; Sensor; Taxifolin.

MeSH terms

  • Adsorption
  • Carbon / chemistry
  • Diffusion
  • Disulfides / chemistry*
  • Drug Contamination
  • Drugs, Chinese Herbal / analysis*
  • Electrochemical Techniques*
  • Electrodes
  • Medicine, Chinese Traditional
  • Molecular Structure
  • Molybdenum / chemistry*
  • Oxidation-Reduction
  • Particle Size
  • Quercetin / analogs & derivatives*
  • Quercetin / analysis
  • Surface Properties

Substances

  • Disulfides
  • Drugs, Chinese Herbal
  • Carbon
  • Molybdenum
  • Quercetin
  • taxifolin
  • molybdenum disulfide