Gō model revisited

Abstract

This review discusses Gō models broadly used in biomolecular simulations. I start with a brief description of the original lattice model study by Nobuhiro Gō. Then, the theory of protein folding behind Gō model, free energy approaches, and off-lattice Gō models are reviewed. I also mention a stringent test for the assumption in Gō models given from all-atom molecular dynamics simulations. Subsequently, I move to application of Gō models to protein dynamical functions. Various extension of Gō models is also reviewed. Finally, some publicly available tools to use Gō models are listed.

Keywords: Gō model; coarse-grained simulation; funnel energy landscape; protein folding; structure-based model.