Inhaled chemotherapy adverse effects: mechanisms and protection methods

Chrysanthi Sardeli; Paul Zarogoulidis; Christoforos Kosmidis; Aikaterini Amaniti; Athanasios Katsaounis; Dimitrios Giannakidis; Charilaos Koulouris; Wolfgang Hohenforst-Schmidt; Haidong Huang; Chong Bai; Nikolaos Michalopoulos; Kosmas Tsakiridis; Konstantinos Romanidis; Panagoula Oikonomou; Konstantina Mponiou; Anastasios Vagionas; Alexandru Marian Goganau; Isaak Kesisoglou; Konstantinos Sapalidis

doi:10.2217/lmt-2019-0007

Inhaled chemotherapy adverse effects: mechanisms and protection methods

Lung Cancer Manag. 2020 Jan 16;8(4):LMT19. doi: 10.2217/lmt-2019-0007.

Authors

Chrysanthi Sardeli¹, Paul Zarogoulidis^{1

2}, Christoforos Kosmidis², Aikaterini Amaniti³, Athanasios Katsaounis¹, Dimitrios Giannakidis¹, Charilaos Koulouris¹, Wolfgang Hohenforst-Schmidt⁴, Haidong Huang⁵, Chong Bai⁵, Nikolaos Michalopoulos¹, Kosmas Tsakiridis⁶, Konstantinos Romanidis⁷, Panagoula Oikonomou⁷, Konstantina Mponiou⁸, Anastasios Vagionas⁹, Alexandru Marian Goganau¹⁰, Isaak Kesisoglou¹, Konstantinos Sapalidis¹

Affiliations

¹ Department of Pharmacology & Clinical Pharmacology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
² Third Department of Surgery, 'AHEPA' University Hospital, Aristotle University of Thessaloniki, Medical School, Thessaloniki, Greece.
³ Anesthesiology Department, 'AHEPA' University Hospital, Aristotle University of Thessaloniki, Medical School, Thessaloniki, Greece.
⁴ Sana Clinic Group Franken, Department of Cardiology/Pulmonology/Intensive Care/Nephrology, 'Hof' Clinics, University of Erlangen, Hof, Germany.
⁵ The Diagnostic & Therapeutic Center of Respiratory Diseases, Shanghai East Hospital, Tongji University, Shanghai, China.
⁶ Thoracic Surgery Department, 'Interbalkan' European Medical Center, Thessaloniki, Greece.
⁷ Second Department of Surgery, University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
⁸ Radiotherapy Department, 'Theageneio' Anti-Cancer Hospital, Thessaloniki, Greece.
⁹ Oncology Department, General Hospital of Kavala, Kavala, Greece.
¹⁰ General Surgery Clinic 1, University of Medicine and Pharmacy of Craiova, Craiova County Emergency Hospital, Craiova, Romania.

Abstract

Lung cancer is still diagnosed at a late stage due to a lack of symptoms. Although there are novel therapies, many patients are still treated with chemotherapy. In an effort to reduce adverse effects associated with chemotherapy, inhaled administration of platinum analogs has been investigated. Inhaled administration is used as a local route in order to reduce the systemic adverse effects; however, this treatment modality has its own adverse effects. In this mini review, we present drugs that were administered as nebulized droplets or dry powder aerosols for non-small-cell lung cancer. We present the adverse effects and methods to overcome them.

Keywords: 5-fluorouracil; bevacizumab; carboplatin; cisplatin; gemcitabine; inhalation; lung cancer; nitrocamptothecine; non-small-cell lung cancer; paclitaxel; taxol.

Publication types

Review