Anti-pruritic and anti-inflammatory effects of natural verbascoside through selective inhibition of temperature-sensitive Ca²⁺-permeable TRPV3 channel

J Dermatol Sci. 2020 Mar;97(3):229-231. doi: 10.1016/j.jdermsci.2020.01.004. Epub 2020 Jan 20.

Authors

Xiaoying Sun¹, Hang Qi¹, Han Wu¹, Yaxuan Qu¹, KeWei Wang²

Affiliations

¹ Department of Pharmacology, Qingdao University School of Pharmacy, Shandong Province, China.
² Department of Pharmacology, Qingdao University School of Pharmacy, Shandong Province, China. Electronic address: wangkw@qdu.edu.cn.

PMID: 31983608
DOI: 10.1016/j.jdermsci.2020.01.004

No abstract available

Publication types

Letter

MeSH terms

Anti-Inflammatory Agents / pharmacology*
Anti-Inflammatory Agents / therapeutic use
Antipruritics / pharmacology*
Antipruritics / therapeutic use
Cymenes / pharmacology
Glucosides / pharmacology*
Glucosides / therapeutic use
HEK293 Cells
Humans
Patch-Clamp Techniques
Phenols / pharmacology*
Phenols / therapeutic use
Pruritus / drug therapy*
Pruritus / immunology
TRPV Cation Channels / agonists
TRPV Cation Channels / antagonists & inhibitors*
TRPV Cation Channels / genetics
TRPV Cation Channels / metabolism
Transfection

Substances

Anti-Inflammatory Agents
Antipruritics
Cymenes
Glucosides
Phenols
TRPV Cation Channels
TRPV3 protein, human
Trpv3 protein, mouse
acteoside
carvacrol