Quorum sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone: An all-rounder in mammalian cell modification

Jiajie Guo; Kaya Yoshida; Mika Ikegame; Hirohiko Okamura

doi:10.1016/j.job.2020.01.001

Quorum sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone: An all-rounder in mammalian cell modification

J Oral Biosci. 2020 Mar;62(1):16-29. doi: 10.1016/j.job.2020.01.001. Epub 2020 Jan 23.

Authors

Jiajie Guo¹, Kaya Yoshida², Mika Ikegame³, Hirohiko Okamura⁴

Affiliations

¹ Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata, Kitaku, Okayama, 770-8525, Japan; Department of Endodontics, School of Stomatology, China Medical University, Nanjing North Street 117, Shenyang, 110002, China. Electronic address: jiajieguo@hotmail.com.
² Department of Oral Healthcare Education, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 770-8504, Japan.
³ Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata, Kitaku, Okayama, 770-8525, Japan.
⁴ Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata, Kitaku, Okayama, 770-8525, Japan. Electronic address: hiro-okamura@okayama-u.ac.jp.

PMID: 31982630
DOI: 10.1016/j.job.2020.01.001

Abstract

Background: Bacteria exhibit multi-cellular social behavior, such as biofilm formation, virulence generation, bioluminescence, or sporulation, through cell-to-cell communication involving a quorum sensing (QS) system capable of sensing species density. Pseudomonas aeruginosa (P. aeruginosa) is a ubiquitous gram-negative opportunistic pathogen that is frequently isolated from immunocompromised patients. It is particularly detected in patients with severe periodontitis and persistent endodontic infections, forcing a rethink of the role of this opportunistic pathogen in oral lesions.

Highlight: N-(3-oxododecanoyl)-l-homoserine lactone (OdDHL) is a pivotal QS molecule, which regulates numerous virulence genes in P. aeruginosa and exhibits broad biological modulation effects in mammalian cells. In this review, we highlight the diverse OdDHL-mediated apoptosis and immunomodulatory effects on host cells. The structural properties, signaling pathways, targeted genes and proteins, and intracellular metabolism of OdDHL are also discussed to clarify the interactions between P. aeruginosa and the host.

Conclusion: The purpose of this review is to identify a valid target for quenching OdDHL, which could potentially eliminate the pathogenic effect of P. aeruginosa.

Keywords: Acyl-Homoserine lactones; Apoptosis; Eukaryotic cells; Immunomodulation; Quorum sensing.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

4-Butyrolactone / analogs & derivatives
Animals
Homoserine* / analogs & derivatives
Humans
Lactones
Pseudomonas aeruginosa
Quorum Sensing*

Substances

Lactones
N-(3-oxododecanoyl)homoserine lactone
Homoserine
4-Butyrolactone