99mTC-sestamibi breast imaging: Current status, new ideas and future perspectives

Nicoletta Urbano; Manuel Scimeca; Virginia Tancredi; Elena Bonanno; Orazio Schillaci

doi:10.1016/j.semcancer.2020.01.007

⁹⁹mTC-sestamibi breast imaging: Current status, new ideas and future perspectives

Semin Cancer Biol. 2022 Sep:84:302-309. doi: 10.1016/j.semcancer.2020.01.007. Epub 2020 Jan 23.

Authors

Nicoletta Urbano¹, Manuel Scimeca², Virginia Tancredi³, Elena Bonanno⁴, Orazio Schillaci⁵

Affiliations

¹ Nuclear Medicine, Policlinico "Tor Vergata", Viale Oxford, 81, 00133, Rome, Italy.
² Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy; University of San Raffaele, Via di Val Cannuta 247, 00166, Rome, Italy; Fondazione Umberto Veronesi (FUV), Piazza Velasca 5, 20122, Milano (Mi), Italy; UniCamillus, Saint Camillus International University of Health Sciences, Rome, Italy.
³ Department of Systems Medicine, School of Sport and Exercise Sciences, University of Rome Tor Vergata, Rome, Italy; Centre of Space Biomedicine, University of Rome Tor Vergata, Rome, Italy.
⁴ Department of Experimental Medicine, University of Rome "Tor Vergata", Via Montpellier, 1, 00133, Rome, Italy; Diagnostica Medica' & 'Villa dei Platani', Neuromed Group, Avellino, 83100, Italy.
⁵ Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy; IRCCS Neuromed, Pozzilli (Is), 86077, Italy. Electronic address: orazio.schillaci@uniroma2.it.

PMID: 31982511
DOI: 10.1016/j.semcancer.2020.01.007

Abstract

Here we proposed the most recent innovations in the use of Breast Specific Gamma Imaging with ⁹⁹mTc-sestamibi for the management of breast cancer patients. To this end, we reported the recent discoveries concerning: a) the implementation of both instrumental devices and software, b) the biological mechanisms involved in the ⁹⁹mTc-sestamibi uptake in breast cancer cells, c) the evaluation of Breast Specific Gamma Imaging with ⁹⁹mTc-sestamibi as predictive markers of metastatic diseases. In this last case, we also reported preliminary data about the capability of Breast Specific Gamma Imaging with ⁹⁹mTc-sestamibi to identify breast cancer lesions with high propensity to form bone metastatic lesions due to the presence of Breast Osteoblast-Like Cells.

Keywords: (99)mTC-sestamibi; Bone metastasis; Breast cancer; Dedicated breast gamma camera; Molecular imaging.

Publication types

Review

MeSH terms

Breast Neoplasms* / diagnostic imaging
Breast Neoplasms* / pathology
Female
Humans
Radionuclide Imaging
Radiopharmaceuticals
Technetium Tc 99m Sestamibi*

Substances

Radiopharmaceuticals
Technetium Tc 99m Sestamibi