Anti-obesity effect of trans-cinnamic acid on HepG2 cells and HFD-fed mice

Zhenyu Wang; Shenghan Ge; Shiyang Li; Huiting Lin; Shaoling Lin

doi:10.1016/j.fct.2020.111148

Anti-obesity effect of trans-cinnamic acid on HepG2 cells and HFD-fed mice

Food Chem Toxicol. 2020 Mar:137:111148. doi: 10.1016/j.fct.2020.111148. Epub 2020 Jan 23.

Authors

Zhenyu Wang¹, Shenghan Ge², Shiyang Li³, Huiting Lin², Shaoling Lin⁴

Affiliations

¹ Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition (Ministry of Education), Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China; College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
² College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
³ College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; State Key Laboratory of Food Safety Technology for Meat Products, Xiamen, Fujian, 361100, China.
⁴ Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition (Ministry of Education), Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China; College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. Electronic address: shaoling.lin@fafu.edu.cn.

PMID: 31982449
DOI: 10.1016/j.fct.2020.111148

Abstract

Trans-cinnamic acid (tCA) is a phenylpropenoic acid, which occurs naturally in a number of plants. In this study, the anti-obese effects of tCA were evaluated in oleic acid (OA)-induced HepG2 cells and high fat diet (HFD)-fed mice. The results showed tCA treatment significantly decreased lipid accumulation in HepG2 cells exposed to OA. Furthermore, administration of tCA (40 mg/kg/day) curbed body weight gains, reduced liver and adipose tissue weight, and ameliorated hepatic steatosis and adipose hypertrophy in mice fed with HFD. In addition, significant decrease in plasma levels of TG, TC and LDL-C were also observed in HFD-fed mice with tCA treatment. Collectively, tCA may play a vital role in preventing and treating diet induced obesity.

Keywords: HFD-Induced mice; HepG2 cells; Hepatic steatosis; Plasma lipid; Trans-Cinnamic acid.

MeSH terms

Animals
Anti-Obesity Agents / therapeutic use*
Body Weight / drug effects
Cinnamates / chemistry
Cinnamates / therapeutic use*
Diet, High-Fat
Dietary Supplements
Eating / drug effects
Fatty Liver / drug therapy*
Fatty Liver / pathology
Hep G2 Cells
Humans
Liver / pathology
Male
Mice, Inbred C57BL
Organ Size / drug effects
Stereoisomerism

Substances

Anti-Obesity Agents
Cinnamates
cinnamic acid