PRES-like presentation in MOG antibody-related demyelination (MARD)

Joel Corbett; Sandeep Bhuta; Kerri Prain; Fabienne Brilot; Arman Sabet; Simon A Broadley

doi:10.1016/j.jocn.2020.01.034

PRES-like presentation in MOG antibody-related demyelination (MARD)

J Clin Neurosci. 2020 Feb:72:453-455. doi: 10.1016/j.jocn.2020.01.034. Epub 2020 Jan 22.

Authors

Joel Corbett¹, Sandeep Bhuta², Kerri Prain³, Fabienne Brilot⁴, Arman Sabet⁵, Simon A Broadley⁵

Affiliations

¹ Department of Neurology, Gold Coast University Hospital, Southport, QLD 4215, Australia. Electronic address: JoelBenjaminCorbett@gmail.com.
² Department of Radiology, Gold Coast University Hospital, Southport, QLD 4215, Australia.
³ Division of Immunology, Pathology Queensland Central Laboratory, Royal Brisbane and Women's Hospital, Herston, QLD 4006, Australia.
⁴ Brain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital, Westmead, NSW 2145, Australia.
⁵ Department of Neurology, Gold Coast University Hospital, Southport, QLD 4215, Australia; School of Medicine, Griffith University, Gold Coast Campus, QLD 4222, Australia.

PMID: 31982280
DOI: 10.1016/j.jocn.2020.01.034

Abstract

A 33-year-old male presented with a progressive four-week history of frontal headache and left visual field impairment. MRI brain confirmed bilateral, asymmetric, occipital vasogenic oedema, suggestive of posterior reversible encephalopathy syndrome (PRES). Serum testing for MOG antibodies was positive, confirming a diagnosis of MOG antibody-related demyelination (MARD). A similar PRES-like pattern of white matter inflammation has been reported previously in neuromyelitis optica spectrum disorder but has not previously been reported in MARD.

Keywords: Myelin oligodendrocyte glycoprotein; Posterior reversible encephalopathy syndrome.

Publication types

Case Reports

MeSH terms

Adult
Autoantibodies / blood
Brain / diagnostic imaging
Demyelinating Autoimmune Diseases, CNS / diagnosis*
Demyelinating Autoimmune Diseases, CNS / diagnostic imaging
Demyelinating Autoimmune Diseases, CNS / immunology
Diagnosis, Differential
Humans
Magnetic Resonance Imaging
Male
Myelin-Oligodendrocyte Glycoprotein / immunology*
Posterior Leukoencephalopathy Syndrome / diagnosis*
Posterior Leukoencephalopathy Syndrome / diagnostic imaging
Posterior Leukoencephalopathy Syndrome / immunology

Substances

Autoantibodies
Myelin-Oligodendrocyte Glycoprotein