Novel approaches for the delivery of therapeutics in ischemic stroke

Saeideh Nozohouri; Ali Ehsan Sifat; Bhuvaneshwar Vaidya; Thomas J Abbruscato

doi:10.1016/j.drudis.2020.01.007

Novel approaches for the delivery of therapeutics in ischemic stroke

Drug Discov Today. 2020 Mar;25(3):535-551. doi: 10.1016/j.drudis.2020.01.007. Epub 2020 Jan 21.

Authors

Saeideh Nozohouri¹, Ali Ehsan Sifat¹, Bhuvaneshwar Vaidya², Thomas J Abbruscato³

Affiliations

¹ Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.
² Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA. Electronic address: bhuvan.vaidya@ttuhsc.edu.
³ Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA. Electronic address: Thomas.abbruscato@ttuhsc.edu.

Abstract

Here, we review novel approaches to deliver neuroprotective drugs to salvageable penumbral brain areas of stroke injury with the goals of offsetting ischemic brain injury and enhancing recovery.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Blood-Brain Barrier / metabolism
Brain Ischemia / drug therapy*
Brain Ischemia / pathology
Drug Approval
Drug Delivery Systems
Humans
Ischemic Stroke / drug therapy*
Ischemic Stroke / pathology
Neuroprotective Agents / administration & dosage*
Neuroprotective Agents / pharmacokinetics
Thrombectomy / methods
Tissue Distribution

Substances

Neuroprotective Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding