An IRON-clad Connection between Aging Organelles

Hongying Shen

doi:10.1016/j.cell.2019.12.037

An IRON-clad Connection between Aging Organelles

Cell. 2020 Jan 23;180(2):214-216. doi: 10.1016/j.cell.2019.12.037.

Author

Hongying Shen¹

Affiliation

¹ Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA; Systems Biology Institute, Yale West Campus, Yale University, West Haven, CT, USA. Electronic address: Hongying.shen@yale.edu.

PMID: 31978339
DOI: 10.1016/j.cell.2019.12.037

Abstract

Lysosome (vacuole) and mitochondria decline interdependently during aging through an unclear mechanism. In this issue of Cell, Hughes et al. (2020) show that defective vacuole-mediated cysteine compartmentalization in aging yeast leads to iron limitation and mitochondrial dysfunction.

Publication types

Comment

MeSH terms

Cysteine*
Homeostasis
Iron*
Mitochondria

Substances

Iron
Cysteine

Grants and funding

R00 GM124296/GM/NIGMS NIH HHS/United States