Accuracy of Imputation for Apolipoprotein E ε Alleles in Genome-Wide Genotyping Data

Eero Vuoksimaa; Teemu Palviainen; Noora Lindgren; Juha O Rinne; Jaakko Kaprio

doi:10.1001/jamanetworkopen.2019.19960

Accuracy of Imputation for Apolipoprotein E ε Alleles in Genome-Wide Genotyping Data

JAMA Netw Open. 2020 Jan 3;3(1):e1919960. doi: 10.1001/jamanetworkopen.2019.19960.

Authors

Eero Vuoksimaa¹, Teemu Palviainen¹, Noora Lindgren², Juha O Rinne^{2

3}, Jaakko Kaprio^{1

4}

Affiliations

¹ Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
² Turku PET Centre, University of Turku, Turku, Finland.
³ Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland.
⁴ Department of Public Health, Clinicum, University of Helsinki, Helsinki, Finland.

Abstract

This diagnostic study evaluates the association of reference panels with imputation quality for 2 single-nucleotide polymorphisms located on the apolipoprotein E (APOE) gene.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Alleles*
Alzheimer Disease / genetics*
Apolipoproteins / genetics*
Biomarkers / blood*
Data Accuracy*
Europe
Female
Genetic Predisposition to Disease
Genome-Wide Association Study / standards*
Humans
Male
Polymorphism, Single Nucleotide*

Substances

Apolipoproteins
Biomarkers