Inhibitory effect of a mixture of herbal drugs (TJ-960, SK) on pentylenetetrazol-induced convulsions in E1 mice

E Sugaya; A Ishige; K Sekiguchi; S Iizuka; A Sugimoto; M Yuzurihara; E Hosoya

doi:10.1016/0920-1211(88)90043-5

Inhibitory effect of a mixture of herbal drugs (TJ-960, SK) on pentylenetetrazol-induced convulsions in E1 mice

Epilepsy Res. 1988 Sep-Oct;2(5):337-9. doi: 10.1016/0920-1211(88)90043-5.

Authors

E Sugaya¹, A Ishige, K Sekiguchi, S Iizuka, A Sugimoto, M Yuzurihara, E Hosoya

Affiliation

¹ Department of Physiology, Kanagawa Dental College, Yokosuka, Japan.

PMID: 3197702
DOI: 10.1016/0920-1211(88)90043-5

Abstract

TJ-960 is a spray-dried mixture of 9 herbal drugs. The convulsions of E1 mice induced by pentylenetetrazol (18 mg/kg) were completely inhibited by p.o. administration of TJ-960 at a daily dose of 1.0 g/kg both in 8-week-old and 4-week-old E1 mice. These findings suggest that TJ-960 has an inhibitory effect on the convulsions of this hereditary animal model of epilepsy.

MeSH terms

Animals
Anticonvulsants / pharmacology*
Dose-Response Relationship, Drug
Drugs, Chinese Herbal / therapeutic use*
Mice
Mice, Neurologic Mutants
Pentylenetetrazole*
Phytotherapy*
Seizures / chemically induced
Seizures / drug therapy*
Seizures / physiopathology

Substances

Anticonvulsants
Drugs, Chinese Herbal
shosaikoto-go-keishika-shakuyakuto
Pentylenetetrazole