Draft Genome Sequence of an Isolate of Extensively Drug-Resistant Mycobacterium tuberculosis from Nepal

Sanjay S Gautam; Kelvin W C Leong; Manoj Pradhan; Y Ibotomba Singh; Sagar K Rajbhandari; Gokarna R Ghimire; Krishna Adhikari; Uma Shrestha; Raina Chaudhary; Gyanendra Ghimire; Sundar Khadka; Ronan F O'Toole

doi:10.1128/MRA.01404-19

Draft Genome Sequence of an Isolate of Extensively Drug-Resistant Mycobacterium tuberculosis from Nepal

Microbiol Resour Announc. 2020 Jan 23;9(4):e01404-19. doi: 10.1128/MRA.01404-19.

Authors

Affiliations

¹ School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia.
² School of Molecular Sciences, College of Science, Health and Engineering, La Trobe University, Victoria, Australia.
³ Department of Microbiology, College of Medicine, Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.
⁴ National Tuberculosis Control Center, Bhaktapur, Nepal.
⁵ HIV Reference Unit, National Public Health Laboratory, Kathmandu, Nepal.
⁶ School of Molecular Sciences, College of Science, Health and Engineering, La Trobe University, Victoria, Australia r.otoole@latrobe.edu.au.
⁷ Trinity College Dublin, Department of Clinical Microbiology, Saint James's Hospital, Dublin, Ireland.

^# Contributed equally.

Abstract

Extensively drug-resistant (XDR) Mycobacterium tuberculosis has become a challenge to the treatment of tuberculosis (TB) in several countries, including Nepal. Here, we report for the first time the draft genome sequence of an isolate of XDR-TB collected in Nepal and describe single-nucleotide variations associated with its extensively drug-resistant phenotype.