Halogenated Dodecaborate Clusters as Agents to Trigger Release of Liposomal Contents

Doaa Awad; Melinda Bartok; Farzin Mostaghimi; Imke Schrader; Neeti Sudumbrekar; Tanja Schaffran; Carsten Jenne; Jonny Eriksson; Mathias Winterhalter; Jürgen Fritz; Katarina Edwards; Detlef Gabel

doi:10.1002/cplu.201402286

Halogenated Dodecaborate Clusters as Agents to Trigger Release of Liposomal Contents

Chempluschem. 2015 Apr;80(4):656-664. doi: 10.1002/cplu.201402286. Epub 2015 Jan 12.

Authors

Doaa Awad^{1

2

3}, Melinda Bartok^{2

3}, Farzin Mostaghimi², Imke Schrader², Neeti Sudumbrekar², Tanja Schaffran², Carsten Jenne⁴, Jonny Eriksson⁵, Mathias Winterhalter³, Jürgen Fritz³, Katarina Edwards⁵, Detlef Gabel^{2

3}

Affiliations

¹ Department of Biochemistry, Faculty of Science, Alexandria University, Moharam Bek, 21511 Alexandria (Egypt).
² Department of Chemistry, University of Bremen, PO Box 330440, 28334 Bremen (Germany).
³ Jacobs University Bremen, Campus Ring 1, 28759 Bremen (Germany).
⁴ Fachbereich C-Anorganische Chemie, Bergische Universität Wuppertal, 42119 Wuppertal (Germany).
⁵ Department of Chemistry-BMC, Uppsala University, Box 579, 75123 Uppsala (Sweden).

PMID: 31973437
DOI: 10.1002/cplu.201402286

Abstract

Halogenated dodecaborates, and especially dodecaiodododecaborate(2-), are found to trigger effectively the release of the contents of phospholipid liposomes, including liposomes containing distearoylphosphatidylcholine and cholesterol, which are used clinically in cancer therapy. The basis of the release is studied through differential scanning calorimetry, cryo-transmission electron microscopy, and atomic force microscopy. Upon administration at high concentrations, drastic morphological changes are induced by the dodecaborates. Their possible use in triggered release is suggested.

Keywords: boron; cluster compounds; cryo-transmission electron microscopy; differential scanning calorimetry; liposomes; triggered release.

Abstract

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