Coinfection With Human Herpesvirus (HHV)-6B in Immunocompetent, Healthy Individuals With Chromosomally Integrated HHV-6A

Hiroki Miura; Tamae Ohye; Kei Kozawa; Fumihiko Hattori; Yoshiki Kawamura; Masaru Ihira; Hiroki Kurahashi; Tetsushi Yoshikawa

doi:10.1093/jpids/piaa009

Coinfection With Human Herpesvirus (HHV)-6B in Immunocompetent, Healthy Individuals With Chromosomally Integrated HHV-6A

J Pediatric Infect Dis Soc. 2021 Mar 26;10(2):175-178. doi: 10.1093/jpids/piaa009.

Authors

Hiroki Miura¹, Tamae Ohye², Kei Kozawa¹, Fumihiko Hattori¹, Yoshiki Kawamura¹, Masaru Ihira³, Hiroki Kurahashi⁴, Tetsushi Yoshikawa¹

Affiliations

¹ Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
² Department of Clinical Laboratory Medicine, Graduate School of Health Sciences, Fujita Health University, Toyoake, Japan.
³ Faculty of Clinical Engineering, Fujita Health University School of Health Sciences, Toyoake, Japan.
⁴ Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.

PMID: 31972018
DOI: 10.1093/jpids/piaa009

Abstract

Immunocompetent sisters with chromosomally integrated human herpesvirus 6A (HHV-6A) transiently excreted HHV-6B genome in their saliva. They did not have past histories of exanthema subitum but had antibodies against HHV-6A and HHV-6B. This suggests that endogenous HHV-6A may modify the clinical features of HHV-6B coinfection.

Keywords: HHV-6B; ciHHV-6; coinfection; saliva.

© The Author(s) 2020. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

MeSH terms

Coinfection*
Herpesvirus 6, Human* / genetics
Humans
Roseolovirus Infections* / diagnosis
Saliva