DLEU1: A Functional Long Noncoding RNA in Tumorigenesis

Chaoying Song; Jiali Zhang; Zongyao Zhao; Yuxia Yang; Di Meng; Jing Wang; Chong Guo; Chengfu Yuan

doi:10.2174/1381612826666200122145305

DLEU1: A Functional Long Noncoding RNA in Tumorigenesis

Curr Pharm Des. 2020;26(15):1742-1748. doi: 10.2174/1381612826666200122145305.

Authors

Chaoying Song^{1

2}, Jiali Zhang^{1

2}, Zongyao Zhao^{1

2}, Yuxia Yang^{1

2}, Di Meng^{1

2}, Jing Wang^{1

2}, Chong Guo^{1

2}, Chengfu Yuan^{1

2

3

4}

Affiliations

¹ China Three Gorges University, School of Medicine, Yichang, 443002, Hubei, China.
² Department of Biochemistry and Molecular Biology, China Three Gorges University, School of Medicine, Yichang, 443002, Hubei, China.
³ Tumor Microenvironment and Immunotherapy Key Laboratory of Hubei province, China Three Gorges University, School of Medicine, Yichang, 443002, Hubei, China.
⁴ Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, China Three Gorges University, School of Medicine, Yichang, 443002, Hubei, China.

PMID: 31969095
DOI: 10.2174/1381612826666200122145305

Abstract

Background: LncRNA DLEU1 participates in various biological processes, playing an indispensable role in the pathophysiology of human diseases, especially in tumorigenesis and other processes. Besides, it may represent a promising target for biotherapy in numerous tumors. The aim of this review was to reveal the pathophysiological functions and mechanisms of lncRNA DLEU1 in different types of cancer.

Methods: In this review, current studies concerning the biological functions and mechanisms of DLEU1 in tumor development are summarized and analyzed; the related researches are collected through a systematic retrieval of PubMed.

Results: DLEU1 is a novel cancer-associated lncRNA that has been proved to be abnormally elevated in various malignancies, containing osteosarcoma, glioma, glioblastoma multiforme, hepatocellular carcinoma, bladder cancer, cervical cancer, non-small cell lung cancer, pancreatic ductal adenocarcinoma, colorectal cancer, oral squamous cell carcinoma, endometrial cancer, gastric cancer, Burkitt lymphoma and ovarian carcinoma. Besides, lncRNA LDEU1 has been demonstrated involving in the procession of proliferation, migration, invasion and inhibition of apoptosis of cancer cells.

Conclusion: Long non-coding RNA DLEU1 is likely to represent an available biomarker or a potential therapeutic target in multiple tumors.

Keywords: DLEU1; Long non-coding RNA; biomarker; multiple tumors; potential therapeutic target; tumorigenesis..

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bone Neoplasms*
Carcinogenesis / genetics
Carcinoma, Non-Small-Cell Lung*
Carcinoma, Squamous Cell*
Cell Line, Tumor
Cell Movement
Cell Proliferation / genetics
Gene Expression Regulation, Neoplastic
Humans
Lung Neoplasms*
Mouth Neoplasms*
RNA, Long Noncoding* / genetics
Tumor Suppressor Proteins

Substances

DLEU1 lncRNA, human
RNA, Long Noncoding
Tumor Suppressor Proteins