Neuromodulation plays a vital role in the prevention and treatment of neurological and psychiatric disorders. Neuromodulation's feasibility is a long-standing issue because it provides the necessity for neuromodulation to realize the desired purpose. A controllability analysis of neural dynamics is necessary to ensure neuromodulation's feasibility. Here, we present such a theoretical method by using the concept of controllability from the control theory that neuromodulation's feasibility can be studied smoothly. Firstly, networks of multiple coupled neural populations with different topologies are established to mathematically model complicated neural dynamics. Secondly, an analytical method composed of a linearization method, the Kalman controllable rank condition and a controllability index is applied to analyze the controllability of the established network models. Finally, the relationship between network dynamics or topological characteristic parameters and controllability is studied by using the analytical method. The proposed method provides a new idea for the study of neuromodulation's feasibility, and the results are expected to guide us to better modulate neurodynamics by optimizing network dynamics and network topology.
Keywords: Neuromodulation’s feasibility; complex network; controllability; the lumped-parameter model.