N-Heterocyclic Carbene Complexes in C-H Activation Reactions

Qun Zhao; Guangrong Meng; Steven P Nolan; Michal Szostak

doi:10.1021/acs.chemrev.9b00634

N-Heterocyclic Carbene Complexes in C-H Activation Reactions

Chem Rev. 2020 Feb 26;120(4):1981-2048. doi: 10.1021/acs.chemrev.9b00634. Epub 2020 Jan 22.

Authors

Qun Zhao¹, Guangrong Meng¹, Steven P Nolan², Michal Szostak¹

Affiliations

¹ Department of Chemistry , Rutgers University , 73 Warren Street , Newark , New Jersey 07102 , United States.
² Department of Chemistry and Center for Sustainable Chemistry , Ghent University , Krijgslaan 281 , 9000 Ghent , Belgium.

Abstract

In this contribution, we provide a comprehensive overview of C-H activation methods promoted by NHC-transition metal complexes, covering the literature since 2002 (the year of the first report on metal-NHC-catalyzed C-H activation) through June 2019, focusing on both NHC ligands and C-H activation methods. This review covers C-H activation reactions catalyzed by group 8 to 11 NHC-metal complexes. Through discussing the role of NHC ligands in promoting challenging C-H activation methods, the reader is provided with an overview of this important area and its crucial role in forging carbon-carbon and carbon-heteroatom bonds by directly engaging ubiquitous C-H bonds.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Chemistry Techniques, Synthetic / methods*
Heterocyclic Compounds / chemical synthesis
Heterocyclic Compounds / chemistry*
Imidazoles / chemistry
Methane / analogs & derivatives*
Methane / chemistry
Organometallic Compounds / chemistry*
Oxazoles / chemistry
Palladium / chemistry*
Thiazoles / chemistry

Substances

Heterocyclic Compounds
Imidazoles
Organometallic Compounds
Oxazoles
Thiazoles
carbene
Palladium
Methane

Grants and funding

R35 GM133326/GM/NIGMS NIH HHS/United States