mi-R4435-2HG promotes proliferation and inhibits apoptosis of cancer cells in ovarian carcinoma by upregulating ROCK2

Jinghui Hu; Li Wang; Wei Zhao; Yujie Huang; Zhe Wang; Heping Shen

doi:10.3892/ol.2019.11204

mi-R4435-2HG promotes proliferation and inhibits apoptosis of cancer cells in ovarian carcinoma by upregulating ROCK2

Oncol Lett. 2020 Feb;19(2):1305-1309. doi: 10.3892/ol.2019.11204. Epub 2019 Dec 11.

Authors

Jinghui Hu¹, Li Wang², Wei Zhao¹, Yujie Huang¹, Zhe Wang¹, Heping Shen³

Affiliations

¹ Department of Gynecology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.
² Department of Gynecology and Οbstetrics, Changzhou Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China.
³ Department of Gynecology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China.

Abstract

The present study aimed to investigate the involvement of long noncoding RNA mi-R4435-2HG in ovarian carcinoma. mi-R4435-2HG and Rho-associated protein kinase 2 (ROCK2) were demonstrated to both be upregulated in ovarian carcinoma. mi-R4435-2HG and ROCK2 were positively correlated in both tumor and healthy tissues. mi-R4435-2HG overexpression mediated the upregulation of ROCK2, while upregulation of ROCK2 did not affect mi-R4435-2HG. Overexpression of mi-R4435-2HG and ROCK2 led to promoted proliferation and inhibited apoptosis of cancer cells, while mi-R4435-2HG and ROCK2 knockdown had the opposite effect. In addition, ROCK2 knockdown attenuated the effects of mi-R4435-2HG overexpression on cancer cell proliferation and apoptosis. Therefore, mi-R4435-2HG promotes proliferation and inhibits apoptosis of cancer cells in ovarian carcinoma by upregulating ROCK2.

Keywords: Rho-associated protein kinase 2; inhibited apoptosis; long noncoding RNA mi-R4435-2HG; ovarian carcinoma; proliferation.