MicroRNA-425-5p Inhibits Lung Cancer Cell Growth in Vitro and in Vivo by Downregulating TFIIB-Related Factor 2

Technol Cancer Res Treat. 2020 Jan-Dec:19:1533033819901115. doi: 10.1177/1533033819901115.

Abstract

Lung cancer is the most common cancer type with increasingly high incidence. MicroRNAs provide the potential biomarkers for lung cancer treatment. Thus, we aimed to investigate the function of microRNA-425-5p in lung cancer development and the underlying mechanisms. MicroRNA-425-5p overexpression inhibited A549 lung cancer cell proliferation in vitro and in vivo. On the other hand, microRNA-425-5p inhibition increased A549 proliferation. Mechanistically, the underlying mechanism by which microRNA-425-5p inhibits lung cancer cell growth was mediated through its ability in targeting and downregulating the TFIIB-related factor 2. Our results for the first time identified microRNA-425-5p as a tumor suppressor in lung cancer. Thus, microRNA-425-5p may serve as a potential therapeutic target for lung cancer.

Keywords: TFIIB-related factor 2; biomarker; cell growth; lung cancer; microRNA-425-5p.

MeSH terms

  • Animals
  • Apoptosis
  • Cell Movement
  • Cell Proliferation*
  • Cell Transformation, Neoplastic
  • Gene Expression Regulation, Neoplastic*
  • Genes, Tumor Suppressor*
  • Humans
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / metabolism
  • Lung Neoplasms / pathology
  • Mice
  • Mice, Nude
  • MicroRNAs / genetics*
  • Signal Transduction*
  • Transcription Factor TFIIIB / metabolism*
  • Tumor Cells, Cultured
  • Xenograft Model Antitumor Assays

Substances

  • BRF2 protein, human
  • MIRN425 microRNA, human
  • MicroRNAs
  • Transcription Factor TFIIIB