HLA-DR antigens and anticardiolipin antibodies in northern Italian systemic lupus erythematosus patients

M Savi; G F Ferraccioli; T M Neri; P Zanelli; P P Dall'Aglio; A Tincani; G Balestrieri; G Carella; R Cattaneo

doi:10.1002/art.1780311216

HLA-DR antigens and anticardiolipin antibodies in northern Italian systemic lupus erythematosus patients

Arthritis Rheum. 1988 Dec;31(12):1568-70. doi: 10.1002/art.1780311216.

Authors

M Savi¹, G F Ferraccioli, T M Neri, P Zanelli, P P Dall'Aglio, A Tincani, G Balestrieri, G Carella, R Cattaneo

Affiliation

¹ Clinical Medicine and Nephrology Department, University of Parma, Italy.

PMID: 3196369
DOI: 10.1002/art.1780311216

Abstract

Eighty systemic lupus erythematosus (SLE) patients attending 3 clinical centers were evaluated immunologically and immunogenetically. No HLA class II antigens were found to be significantly associated with SLE in these patients. A highly significant (P = 6.17 x 10(-7) association was observed between anticardiolipin antibodies and DR7. A lesser association (P less than 0.025) was also observed between DR2 and/or DR3 and anti-Ro (SS-A) antibodies. No relationship was found between any DR antigen and anti-Sm/RNP, anti-double-stranded DNA, or anti-La (SS-B) antibodies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Autoantibodies / analysis*
Cardiolipins / immunology*
Child
Cohort Studies
Female
HLA Antigens / analysis
HLA-DR Antigens / analysis*
Humans
Italy
Lupus Erythematosus, Systemic / immunology*
Male
Middle Aged

Substances

Autoantibodies
Cardiolipins
HLA Antigens
HLA-DR Antigens