Rolipram treatment during consolidation ameliorates long-term object location memory in aged male mice

Neurobiol Learn Mem. 2020 Mar:169:107168. doi: 10.1016/j.nlm.2020.107168. Epub 2020 Jan 19.

Abstract

Normal aging is accompanied by cognitive and memory impairments that negatively impact quality of life for the growing elderly population. Hippocampal function is most vulnerable to the deleterious effects of aging, and deficits in hippocampus-dependent memories are common amongst aged individuals. Moreover, signaling networks such as the cAMP/PKA/CREB pathway, which are critical for memory consolidation, are dampened in healthy aged subjects. Phosphodiesterase (PDE) enzymes that break down cAMP are also affected by aging, and increased break down of cAMP by PDEs may contribute to reduced activity of the cAMP/PKA/CREB signaling network in the brain of aged individuals. Here, we report that the PDE4 inhibitor rolipram administered during consolidation of hippocampus-dependent object location memory improves aged-related spatial memory deficits in aged mice.

Keywords: Aging; CREB; Hippocampus; PDE4; Spatial memory; cAMP.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / physiology*
  • Aging / psychology*
  • Animals
  • Male
  • Memory Consolidation / drug effects
  • Memory Consolidation / physiology*
  • Memory, Long-Term / drug effects
  • Memory, Long-Term / physiology*
  • Mice, Inbred C57BL
  • Phosphodiesterase 4 Inhibitors / administration & dosage*
  • Rolipram / administration & dosage*

Substances

  • Phosphodiesterase 4 Inhibitors
  • Rolipram