Cellular Internalization and Biocompatibility of Periodic Mesoporous Organosilica Nanoparticles with Tunable Morphologies: From Nanospheres to Nanowires

Yevhen Fatieiev; Jonas G Croissant; Kholod Alamoudi; Niveen M Khashab

doi:10.1002/cplu.201600560

Cellular Internalization and Biocompatibility of Periodic Mesoporous Organosilica Nanoparticles with Tunable Morphologies: From Nanospheres to Nanowires

Chempluschem. 2017 Apr;82(4):631-637. doi: 10.1002/cplu.201600560. Epub 2017 Jan 31.

Authors

Yevhen Fatieiev¹, Jonas G Croissant¹, Kholod Alamoudi¹, Niveen M Khashab¹

Affiliation

¹ Smart Hybrid Materials Laboratory (SHMs), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.

PMID: 31961586
DOI: 10.1002/cplu.201600560

Abstract

This work describes the sol-gel syntheses of para-substituted phenylene-bridged periodic mesoporous organosilica (PMO) nanoparticles (NPs) with tunable morphologies ranging from nanowires to nanospheres. The findings show the key role of the addition of organic co-solvents in the aqueous templates on the final morphologies of PMO NPs. Other factors such as the temperature, the stirring speed, and the amount of organic solvents also influence the shape of PMO NPs. The tuning of the shape of the PMO nanomaterials made it possible to study the influence of the particle morphology on the cellular internalization and biocompatibility.

Keywords: biocompatibility; mesoporous materials; nanoparticles; organosilica; silsesquioxanes.