In Situ Growth of Covalent Organic Framework Shells on Silica Microspheres for Application in Liquid Chromatography

Lu-Liang Wang; Cheng-Xiong Yang; Xiu-Ping Yan

doi:10.1002/cplu.201700223

In Situ Growth of Covalent Organic Framework Shells on Silica Microspheres for Application in Liquid Chromatography

Chempluschem. 2017 Jun;82(6):933-938. doi: 10.1002/cplu.201700223.

Authors

Lu-Liang Wang¹, Cheng-Xiong Yang¹, Xiu-Ping Yan^{1

2}

Affiliations

¹ College of Chemistry, Research Center for Analytical Sciences, Tianjin Key Laboratory of Molecular Recognition and Biosensing, State Key Laboratory of Medicinal Chemical Biology, Nankai University, 94 Weijin Road, Tianjin, 300071, China.
² Collaborative Innovation Center of Chemical Science and Engineering, 94 Weijin Road, Tianjin, 300071, China.

PMID: 31961565
DOI: 10.1002/cplu.201700223

Abstract

A facile, in situ growth strategy for the synthesis of monodispersed COF@SiO₂ microspheres is reported. The microspheres have uniform and controllable COF shells, and are used as the stationary phase for HPLC. The TpBD COF, constructed from 1,3,5-triformylphloroglucinol (Tp) and benzidine (BD), is taken as the COF shell, and aminosilica (SiO₂ -NH₂ ) is employed as the core to support the TpBD shell. The TpBD shell thickness is adjusted by controlling the concentrations of the Tp and BD monomers. The TpBD@SiO₂ packed columns show excellent hydrophobic selectivity, and good reproducibility for the separation of neutral (toluene and ethylbenzene, polycyclic aromatic hydrocarbons), acidic (hydroquinone, p-cresol, and p-chlorophenol), and basic molecules (nucleobases, nucleosides, and deoxynucleosides).

Keywords: core-shell composites; covalent organic frameworks; hydrophobic effect; liquid chromatography; stationary phase.

Abstract

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