3D Micropatterned All-Flexible Microfluidic Platform for Microwave-Assisted Flow Organic Synthesis

Deniz Hur; Mehmet G Say; Sibel E Diltemiz; Fatma Duman; Arzu Ersöz; Rıdvan Say

doi:10.1002/cplu.201700440

3D Micropatterned All-Flexible Microfluidic Platform for Microwave-Assisted Flow Organic Synthesis

Chempluschem. 2018 Jan;83(1):42-46. doi: 10.1002/cplu.201700440.

Authors

Deniz Hur^{1

2}, Mehmet G Say^{2

3}, Sibel E Diltemiz^{1

2}, Fatma Duman¹, Arzu Ersöz^{1

2}, Rıdvan Say^{1

2}

Affiliations

¹ Science Faculty, Chemistry Department, Anadolu University, Yunus Emre Campus, 26470, Eskişehir, Turkey.
² Bionkit Co. Ltd., Anadolu University Teknopark, 26470, Eskisehir, Turkey.
³ Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, 60174, Norrköping, Sweden.

PMID: 31957319
DOI: 10.1002/cplu.201700440

Abstract

A large-area, all-flexible, microwaveable polydimethoxysilane microfluidic reactor was fabricated by using a 3D printing system. The sacrificial microchannels were printed on polydimethoxysilane substrates by a direct ink writing method using water-soluble Pluronic F-127 ink and then encapsulated between polydimethoxysilane layers. The structure of micron-sized channels was analyzed by optical and electron microscopy techniques. The fabricated flexible microfluidic reactors were utilized for the acetylation of different amines under microwave irradiation to obtain acetamides in shorter reaction times and good yields by flow organic synthesis.

Keywords: 3D printing; acylation; flexible microfluidic devices; flow synthesis; microwave chemistry.