LOS in The Dysbiotic Gut

Katherine Z Sanidad; Melody Y Zeng

doi:10.1016/j.chom.2019.12.009

LOS in The Dysbiotic Gut

Cell Host Microbe. 2020 Jan 8;27(1):11-13. doi: 10.1016/j.chom.2019.12.009.

Authors

Katherine Z Sanidad¹, Melody Y Zeng²

Affiliations

¹ Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York City, NY, USA; Department of Pediatrics, Weill Cornell Medicine, New York City, NY, USA.
² Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York City, NY, USA; Department of Pediatrics, Weill Cornell Medicine, New York City, NY, USA; Immunology & Microbial Pathogenesis Graduate Program, Weill Cornell Medicine, New York City, NY, USA. Electronic address: myz4001@med.cornell.edu.

Abstract

The neonatal gut microbiome undergoes dynamic changes in response to many nutritional and environmental variables. A recent study by Singer et al. in Nature Medicine elucidates several mechanisms to inhibit the expansion of gut-derived pathobionts in a dysbiotic neonatal gut and prevent these pathobionts from disseminating systemically and causing sepsis in neonatal mice.

Publication types

Comment

MeSH terms

Animals
Animals, Newborn
Dysbiosis
Gastrointestinal Microbiome*
Mice
Sepsis*

Grants and funding

K01 DK114376/DK/NIDDK NIH HHS/United States