Clec2d Joins the Cell Death Sensor Ranks

Carlos Del Fresno; David Sancho

doi:10.1016/j.immuni.2019.12.015

Clec2d Joins the Cell Death Sensor Ranks

Immunity. 2020 Jan 14;52(1):6-8. doi: 10.1016/j.immuni.2019.12.015.

Authors

Carlos Del Fresno¹, David Sancho²

Affiliations

¹ Immunobiology Lab, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid 28029, Spain.
² Immunobiology Lab, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid 28029, Spain. Electronic address: dsancho@cnic.es.

PMID: 31951550
DOI: 10.1016/j.immuni.2019.12.015

Abstract

Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. In this issue of Immunity, Lai et al. (2020) uncover a role for the C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necrosis and thus contributes to inflammation and immunopathology.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cell Death
Histones*
Humans
Inflammation
Lectins, C-Type*
Necrosis
Receptors, Cell Surface

Substances

CLEC2D protein, human
Histones
Lectins, C-Type
Receptors, Cell Surface