Prime Editing: Precision Genome Editing by Reverse Transcription

Jun Yan; Ann Cirincione; Britt Adamson

doi:10.1016/j.molcel.2019.12.016

Prime Editing: Precision Genome Editing by Reverse Transcription

Mol Cell. 2020 Jan 16;77(2):210-212. doi: 10.1016/j.molcel.2019.12.016.

Authors

Jun Yan¹, Ann Cirincione², Britt Adamson³

Affiliations

¹ Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
² Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
³ Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. Electronic address: badamson@princeton.edu.

PMID: 31951546
DOI: 10.1016/j.molcel.2019.12.016

Abstract

Genome editing is a method for making targeted sequence changes to the genomes of living cells. Prime editing, recently reported by Anzalone et al. (2019), is a new technology that uses reverse transcription to "write" programmed sequence changes into genomic DNA and thus promises significant technical advances.

Publication types

Comment

MeSH terms

DNA
Gene Editing*
Genome
Reverse Transcription*

Substances

DNA

Grants and funding

T32 HG003284/HG/NHGRI NIH HHS/United States