Cytological diagnosis of patients with extramammary Paget's disease of the vagina

Qijun Chen; Yan Qiu; Lian Xu; Xiao Tang; Kaixuan Yang; Wei Wang

Cytological diagnosis of patients with extramammary Paget's disease of the vagina

Int J Clin Exp Pathol. 2018 Jul 1;11(7):3765-3769. eCollection 2018.

Authors

Qijun Chen¹, Yan Qiu², Lian Xu¹, Xiao Tang¹, Kaixuan Yang¹, Wei Wang¹

Affiliations

¹ Department of Pathology, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University Chengdu, Sichuan, China.
² Department of Pathology, West China Hospital, Sichuan University Chengdu, Sichuan, China.

PMID: 31949761
PMCID: PMC6962854

Abstract

Extramammary Paget's Disease (EMPD), also called extramammary eczematoid carcinoma, is classified as primary and secondary EMPD based on the pathogenic mechanism. The origin of the Paget cells of primary EMPD is still controversial. Apocrine or eccrine gland cells, such as Bartholin's gland, and intraepidermal pluripotent keratinocyte stem cells have been considered possible originating cells of primary EMPD. Secondary EMPD usually originates from the malignancies of rectum, cervix, and urinary bladder. We report a case of a 58-year-old woman suffering from intermittent vaginal bleeding for half a year, who was diagnosed as EMPD by vaginal cytology.

Keywords: Vagina; extramammary Paget’s disease.

Publication types

Case Reports